Thrust 3

Rational Design of Interactive Biomaterials

Overall Scientific Challenge

The overall challenge of Thrust 3 is to improve understanding of the effect of physical and chemical cues of surfaces on cellular behavior across a range of length scales. The knowledge gained will be used to develop in-silico models that will enable accelerated design and fabrication of new interactive biomaterials and devices. Biomaterials are synthetic or natural substances that are engineered to interact directly with biological systems and influence structural functions. Recently, major advances in cellular and molecular technology have resulted in a new generation of smart biomaterials. While cells can respond to chemical features of underlying substrates containing domains as small as sub-nm, it is the topographical features of the substrates, from a nanometer to mesoscale, that effectively modulate many responses including adhesion, migration, proliferation, differentiation, metabolism and apoptosis.

The Thrust 3 challenges will be addressed systematically. During the first two years, new building blocks will be prepared and surface modified where appropriate. As these are made available, we will begin assembling them into 3D structures. In all cases, key chemical, rheological, and topological data will be collected and sent to the MCC for inclusion into databases. Beginning with simple, known materials, we will be developing protocols for measuring cellular response to surfaces and fabricated structures. As new materials become available, these will be tested similarly and the results sent back to the MCC for expanding databases and for the development of design tools. As the program progresses, tools from the MCC will enable the design and construction of second generation materials and fabricated structures. These, in turn, will undergo chemical and biological testing. Results from simulations will inform the design of second generation materials in advanced years of the project.


Publications (as of May 13, 2019)

Searchable Spreadsheet: may be sorted by Author Last Name, Article Title, Publication Name, Publication Year, MADE in SC Thrust/Research Cluster, or MADE in SC Project Year and includes link to view article online

Year 1

Year 2


CONFERENCE PAPERS, POSTERS OR PRESENTATIONS

Searchable Spreadsheet: may be sorted by Author Last Name, Title, Type, Location, Year, MADE in SC Thrust/Research Cluster, or MADE in SC Project Year

Year 1

  • Hurlbert, Jason, Presentation, 2017, Enzymatic Degradation of Hemicellulosic Polysaccharides for Industrial Applications, Materials Science and Technology, Pittsburgh, PA
  • Mei, Ying, Presentation, 2018, Development of alginate-based vasculogenic hydrogel for biofabrication, MADE in SC Industrial Engagement and Advisory Board Meeting, Columbia, SC
  • Schiller, Ulf, Presentation, 2018, Simulation-driven optimization of stents for treatment of brain aneurysms, International Conference on Discrete Simulation of Fluid Dynamics, Worcester, MA
  • Wang, Fang; Schiller, Ulf, Presentation, 2018, Mesoscopic simulation of transport phenomena in fibrous porous media, International Conference for Mesoscopic Methods in Engineering in Science, Newark, DE

Year 2

  • Radcliff, Jay, Poster, 2018, Synthesis and characterization of alginate-polypyrrole aerogels functionalized with dodecanethiol, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA
  • Drake, Andrew; Hanks, Timothy, Poster, 2018, Synthesis and characterization of alginate-polypyrrole aerogels functionalized with dodecanethiol, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA
  • Gregory, Arica; Miller, Emily; Alexander-Bryant, Angela, Poster, 2018, Implantable peptide-hydrogel drug delivery system for treating glioblastoma multiforme, Biomedical Engineering Society, Atlanta, GA
  • Gregory, Arica; Miller, Emily; Alexander-Bryant, Angela, Presentation, 2018, Implantable peptide-hydrogel drug delivery system for treating glioblastoma multiforme, Biomedical Engineering Society, Atlanta, GA
  • Miller, Emily; Alexander-Bryant, Angela, Poster, 2018, Liposomal Combination Drug and siRNA Delivery to Combat Drug-Resistant Ovarian Cancer, Biomedical Engineering Society, Atlanta, GA
  • Miller, Emily; Alexander-Bryant, Angela, Presentation, 2018, Liposomal Combination Drug and siRNA Delivery to Combat Drug-Resistant Ovarian Cancer, Biomedical Engineering Society, Atlanta, GA
  • Samac, Timothy; Alexander-Bryant, Angela, Poster, 2018, Comparison of Real-Time Imaging and Endpoint Analysis of Drug Therapeutic Efficacy in Glioblastoma Multiforme Cells, Biomedical Engineering Society, Atlanta, GA
  • Samac, Timothy; Mbiki, Sarah; Gilmore, Jordon; Alexander-Bryant, Angela, Presentation, 2018, Comparison of Real-Time Imaging and Endpoint Analysis of Drug Therapeutic Efficacy in Glioblastoma Multiforme Cells, Biomedical Engineering Society, Atlanta, GA
  • Yunus, Ahmed; Petty, Jeff, Poster, 2018, Fluorescence Anisotropy Studies of DNA-Fluorescence anisotropy studies of DNA-bound silver Clusters, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA
  • Brady, Cheyenne; Evers, Austin; Sahoo, Pabitra; Twiss, Jeffrey; Larsen, Jessica, Presentation, 2018, Optimization of Polymersomes for Delivery of Nerve-Regenerating Peptides, Biomedical Engineering Society, Atlanta, GA
  • Hanks, Timothy, Presentation (invited), 2018, Functionalization of intrinsically conductive polymer films and nanoparticles by thiol-terminated hydrophilic polymers, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA
  • Larsen, Jessica, Presentation, 2018, Polymersomes Deliver Active Enzyme to the Brain of Felines as a Treatment of GM1 Neurodegeneration, Biomedical Engineering Society, Atlanta, GA
  • Mei, Ying, Presentation, 2019, The development of vasculogenic hydrogel for bioprinting, Charleston Regenerative Medicine Workshop, Charleston, SC
  • Ortitz Piccard, Selina; Chavis, Byrson; Cai, Li; Jiang, Hong; Wang, Qian, Presentation, 2018, Development of novel glycan-functionalized viral nanoparticles for cell targeting, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA
  • Wetherill, Richard; Hanks, Timothy, Presentation, 2018, Biologically-triggered release of organic dopants from functionalized intrinsically conducting polymer composites, Southeastern Regional Meeting of the American Chemical Society, Augusta, GA